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COSEAL Surgical Sealant
COSEAL Surgical Sealant
Baxter

Information contained in this page is intended for US Healthcare Professionals Only

The rigth balance of strength, elasticity and time-to-resorptiong
  1. At 5 seconds—Gels and Adheres1
    In the first 5 seconds, COSEAL Surgical Sealant polymerizes to form a hydrogel.4
  2. At ~60 seconds—Full Seal Achieved1
    At 1 minute, COSEAL Surgical Sealant achieves a full mechanical seal to manage suture hole bleeding.1,2
  3. Works independent of the Coagulation Cascade
    COSEAL Surgical Sealant forms a direct mechanical barrier to blood flow, and is therefore unaffected by the patient’s coagulation status.4,5
  4. COSEAL Surgical Sealant is composed of two biocompatible polyethylene glycols (PEGs) that rapidly cross-link with tissue and synthetic graft materials (composed of PTFE or Dacron).1

Selected Important Risk Information


  • Apply only to dry fields in a thin layer1
  • Wait at least 60 seconds post-application before applying irrigation, contacting the sealant, or restoring circulation and resuming procedure1
  • COSEAL Surgical Sealant swells up to four times its volume within 24 hours of application and additional swelling occurs as the gel resorbs1

COSEAL Surgical Sealant Indication

COSEAL is indicated for use in vascular reconstructions to achieve adjunctive hemostasis by mechanically sealing areas of leakage.

COSEAL Important Risk Information

  • COSEAL is not to be used in place of sutures, staples or mechanical closure.
  • COSEAL swells up to four times its volume within 24 hours of application and additional swelling occurs as the gel absorbs. Therefore, surgeons should consider the maximum swell volume and its possible effects on surrounding anatomic structures potentially sensitive to compression.

For more Information, please see Detailed Important Risk Information and Instructions For Use.


References:
  1. COSEAL Surgical Sealant Instructions for Use, Hayward, CA: Baxter Healthcare Corporation. March 2009.
  2. Hagberg RC, Safi HJ, Sabik J, et al. Improved intraoperative management of anastomotic bleeding during aortic reconstruction: Results of a randomized controlled trial. Am Surg. 2004;70: 307-311.
  3. Glickman M, Gheissari A, Money S, et al. A polymeric sealant inhibits anastomotic suture hole bleeding more rapidly than Gelfoam/Thrombin. Arch Surg. 2002;137: 326-331.
  4. Hill A, Estridge TD, Maroney M, et al. Treatment of suture line bleeding with a novel synthetic surgical sealant in a canine iliac PTFE graft model. J Biomed. 2001;58: 308-312.
  5. Natour E, Suedkamp M, Dapunt OE. Assessment on the effect of blood loss and transfusion requirements when adding a polyethylene glycol sealant to the anastomotic closure of aortic procedures: a case-control analysis of 102 patients undergoing Bentall procedures. J Cardiothorac Surg. 2012;7:105.