COSEAL Surgical Sealant Indication
COSEAL is indicated for use in vascular reconstructions to achieve adjunctive hemostasis by mechanically sealing areas of leakage.
COSEAL Important Risk Information
- COSEAL is not to be used in place of sutures, staples or mechanical closure.
- COSEAL swells up to four times its volume within 24 hours of application and additional swelling occurs as the gel absorbs. Therefore, surgeons should consider the maximum swell volume and its possible effects on surrounding anatomic structures potentially sensitive to compression.
- COSEAL Surgical Sealant Instructions for Use, Hayward, CA: Baxter Healthcare Corporation. March 2009.
- Hagberg RC, Safi HJ, Sabik J, et al. Improved intraoperative management of anastomotic bleeding during aortic reconstruction: Results of a randomized controlled trial. Am Surg. 2004;70: 307-311.
- Glickman M, Gheissari A, Money S, et al. A polymeric sealant inhibits anastomotic suture hole bleeding more rapidly than Gelfoam/Thrombin. Arch Surg. 2002;137: 326-331.
- Hill A, Estridge TD, Maroney M, et al. Treatment of suture line bleeding with a novel synthetic surgical sealant in a canine iliac PTFE graft model. J Biomed. 2001;58: 308-312.
- Natour E, Suedkamp M, Dapunt OE. Assessment on the effect of blood loss and transfusion requirements when adding a polyethylene glycol sealant to the anastomotic closure of aortic procedures: a case-control analysis of 102 patients undergoing Bentall procedures. J Cardiothorac Surg. 2012;7:105.